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KMID : 0903520070500040352
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2007 Volume.50 No. 4 p.352 ~ p.357
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Effect of Extracts for Herbal Medicines on the Inhibition of Whole Blood Aggregation
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Jeon Won-kyung
Yoo Bo Kyung
Kim Yeong-Eun
Park Sun-Ok
Park Sun-Min
Ko Byoung-Seob
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Abstract
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For a correlation to study the five tastes and efficacies in oriental medicine concepts, we used herbal medicines with bitter taste character in traditionally effective and experimental methods. In this study, we tested the in vitro effect of 20 typical kinds of herbal medicines with bitter taste on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, 3 kinds of hot water extracts and 2 kinds of 70% ethanol extracts showed the significant inhibiting effect on whole blood aggregation (***p < 0.001). In particular, Coptidis Rhizoma (Coptis chinensis) extracts were selected as the most effective candidate with a strong grade of bitter taste through the sensory test of trained panels. The results from this exper- iment provide pharmacological evidence for the traditional use of bitter tasting herbs with tradi- tional medicine theory, suggesting that strong bitter taste herbs could be help problems of blood circulation more than mild bitter tasting herbs.
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KEYWORD
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five tastes, bitter taste, herbal medicines, platelet aggregation, sensory test
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